Must be lots of folks completing the drive ... Here is my response to a similar post.
We just completed our 25th drive down and are currently in Orlando. We are from central CT. Left at about 5am, stopped in Florence SC (around 740 miles) at 6pm or so. Always target a Holiday Inn Express -- predictable, clean, great beds, reasonable price. Get up and leave around 7:30 and get to our house in Orlando (20 minutes from Epcot, near the airport) at around 3pm (approx. 450 miles).
We never drive straight through. On the return we will leave here around 7am and go to Emporia Va, about 700 miles, Next day leave at 7am for the absolutely torturous remaining 500 miles. It is ---- by a long margin --- the worst part of the round trip.
We are in our "early" 60s now. When we first started driving we would go all the way to Hardeeville SC the first day, almost 900 miles. Those days are gone and Florence is a decent first day target.
We don't stop much. This last trip was our first with our new 2021 Toyota Sienna, which is a hybrid and has a range of almost 550 miles. One gas/lunch stop on the first day, then fill up when we get to our destination and are then ready for day 2.
We have found that we would rather get to the days destination around 5 or 6 pm as opposed to going until 8 or 9. Gives us a little time to grab a bite and rest for the next days journey.
mac_tlc