Hi lori! Not sure how significant you are talking about, but I can tell you that after losing 60 pounds I have excess flesh that hangs that is really hard to tone up. You can tone to a certain extent, but if there are certain areas that if they carried the most weight that they are really hard to firm up. My sister lost 100# and she was an exercise fiend and tried everything to no avail, she finally had a tummy tuck and feels so much better about her body. But I know a tummy tuck is not for everyone.