I always rent a regular sized scvooter from Randy's Mobility and we always rent a car. If the vehicle is a small SUV or smaller, we do take the seat off before lifting the scooter into the back. If we have a full sized SUV or a minivan, we can lift the entire scooter into the car in one piece. Heavy but definitely better than constantly taking the scooter apart and putting it back together. My problems are knees and lungs, so DH and I can lift. At home I have a Fold n' Go and I can load it myself into my car.