We drove down Daytona Weekend and wanted to avoid 95 in that area. We took 295 in Jacksonville, to Rt. 10 west, to 301 south. 301 merges with 27 and that will take you to either the FL Turnpike or 192 in Kissimmee. While I found 301 scenic at the beginning, once we got past Gainsville we went from doing 50 mph on a pretty deserted 4 lane road, to 50mph in traffic, stop light, stop light, stop light......50mph stop light, stop light, stop light...etc. It was a very frustrating after being in the car for 23 hours. However, I think the Daytona traffic would've made me crazier.