The difference is minimal really - Rio Grande rooms are closer to the river Rio Grande and the Eldorado Rooms are closer to main reception and guest services. As regards to the contents of the rooms, there is no difference.
I wouldn't pay extra to stay in any of the supplemented rooms at either the Santa Fe or the Cheyenne, as the rooms themselves are all the same, and you are no further than about 3 minutes walk from either the reception block or the start of the walkway to the parks, whichever room you are in .
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