I was advised that parking a car is expensive and a hassle in SF. You can catch a shuttle (we used Super Shuttle) at SFO and take it to the hotel for about $35 for two people. The FAirmont has a Hertz rental car desk in the lobby. Our trip went very well because we used public transportation in the city until we were ready to leave and took a bus tour to get over the Golden Gate to Muir Woods National Forest and Sausalito. We saved the places we wanted to drive to (Golden Gate Bridge and Ocean Beach) until the day of departure when we picked up our rental car. If cost is no object you can rent a car and use the hotel garage - but be prepared for an extra $30 a day charge and the aggravation of finding parking places. For a trip of a week or more I would get a rental car but for a 3 day stay in the City I wouldn't get the car until the day of departure.