Now we've never done the Ripley's in Orlando. We have done it in Niagara Falls, Pigeon Forge, and I wanna say Mrytle Beach (but I might be wrong and it could of been somewhere else). Anyhow, w/ all the other things Orlando has to offer, I don't think this would make my list.
It never takes us more than an hour to go through-- and well I usually do it to amuse my dh. I find them to be incredibly cheesy. Personally, I'd kick off my arrival night w/ some time at DTD or even CityWalk if you're more of a Universal fan.