We were at work one day and a woman I work with was very very flustered and stood up and announced "I can't take this no much" we laughed all day about it and now when its just too much we all say it.
"busier than a one-legged man in a a$$ kicking contest"
(I don't know if the OP wanted a favorite pod-crew quote ... but this is from one of my best friends, Bob (not Bawb - another Bob) who is FULL of funny quotes).