When you use Priceline for air, you need to NOT count on doing anything else on your "travel" days but travelling. So, if you plan on taking a 7-day vacation, assume 9 days away from home, because the first and last will be travel-only days. It can make a difference in the number of hotel nights you will need, so take that into account. (though you can also Priceline airport hotels if you need a throwaway night for an early departure or really late arrival.)
You might get lucky and get good flight times, but if you do, that's essentially a bonus. For you this is probably not such a hardship, b/c coming that distance, your travel days are probably normally kind of a write-off as far as fun is concerned. It's a huge drawback for East Coasters, b/c they tend to count on having fun-time on their first and last day and blowing less than 6 hrs. each way on travel, so long layovers and early returns are really not worth it for them. (I'm only an hour behind in the Midwest, so it's pretty harsh for me, too.)
You can go to biddingfortravel.com and also betterbidding.com to see what flight times other people may have gotten on your route. The odds are fairly good that you would end up on similarly scheduled flights (it is by no means guaranteed, of course, and if too much time has passed, the schedule may have changed a lot, but past performance can be a useful reference guide.)