There are no preferred buildings in the POR or the POFQ. Quite honestly the POFQ is small enough that you can not go wrong in any building. I would not even pay extra for a waterview room since you do not have a private balconey, but that is just me. I have stayed at the POFQ several time and I really love it. The themeing is great and each building is close to the main building without walking too far. I like building 5 the best, but we've stayed in #2 and #3 and they are great locations too.
As far as I know the only moderate resort that has the preferred buildings is the CBR.