The six of us stayed in one room; we officially counted as 5 because our youngest was only 1 year old. The room was a little tight, especially with the trundle pulled out, but we did just fine.
Stayed in Alligator Bayou and were very happy (didn't like the other side). The grounds are very beautiful. Our kids our nature lovers and they loved the marshes, the trails, the birds, being on the river, etc. The pool was great fun, as was the playground. I think a lot depends on what kind of things your kids are into. If they particularly love nature and walking on trails, they'll love POR. The trails meander A LOT and getting from Point A to Point B takes longer than you might think. If you don't mind that, great. If you do mind that, probably not great.
We loved taking the boat to DTD and did so a few times. We also took it to POFQ once for breakfast. We didn't like POFQ much at all for the same reason that a lot of people prefer it - things were too close together for us.
Bus transportation was easy and fine, but on our late night back from MK, it was a long walk back to our room with three sleeping children!