I own a 2001 Acura MDX, which is what they based on the Pilot on. I absolutely LOVE my MDX, and it gets 25 mpg when I take it on a road trip. I get about 18 mpg when running it in town only, which is very rare. I usually average about 21-22 mpg when doing a combo of city and highway driving. I have had no problems with it, and 2001 was the first year they came out with the MDX.
A woman our office bought a 2003 Chevy Trailblazer about 6 months ago, and it goes in the shop for various problems at least once a month. I don't know if she just got a lemon, or if that is indicative of GM vehicles.
Say what you will about American vs. foreign, but I need good reliable transportation, and Honda has always provided that for me. Before I owned the MDX, I had 2 Honda Accords that were great. I will probably never buy American until they can complete with the quality of the Japanese cars.