Hi... Greetings from South Jersey!!
We have done the drive several times over the years...with 4 kids packed in the van! Whew!
We would usually leave around 5 - 6pm ... after work so my DH didn't lose a day's pay ... then drive south on 95 till about 11pm or so. That usually got us just into NC before we got too tired.
Next morning, up and out early, depending on traffic in Jacksonville we would get to WDW around dinner time.
We drove home straight from WDW one time. It took us 16 hours. That was hard.
Places to stop...there are so many detours you could take...Washington DC, numerous battlefields, Williamsburg, South of the Border, Savannah, Charleston, Atlanta, ... one of our favorites was St. Augustine, the kids really remember that stop. They also enjoyed Kennedy Space Center and Gatorland in Kissimmee (although I'm getting off subject...sorry

) If you belong to
AAA, you might want to stop in and get some of the tour books that they publish, free with your membership. They list every little tourist attraction in every state along with restaurants and hotel listings.