You can bypass Downtown Orlando via the Greenway. It's wonderful and brand new. You'll need about $6-$7.00 in tolls, preferably quarters then you can go through the exact change booths.
Taking I-4 to TOLL 417 in Sanford is a good option to bypass all of the craziness as it's Orlando's eastern beltway. You exit 95 onto I-4 as normal, then follow these directions:
1. Take exit 101B for FL -417 toward International Airports/ Sanford go 1.3 mi
2. Merge onto Florida 417 Toll S; go 49.0 mi
3. Take exit 6 for International Dr/FL -536 toward FL-535/ I-4 E; go 0.7 mi
4. Slight left at World Center Dr go 0.6 mi.
5. Take the 1st right onto S Apopka Vineland Rd go 2.1 mi
6. Turn left at Palm Pkwy; go 62 ft
7 Continue onto County Rd 535/State Rd 535/Winter Garden Vineland Rd8. Turn left on Buena Vista Drive
I really recommend this - we have driven 4 times in the past year and a half and by far, this was the best tip for avoiding Orlando traffic. So much less stressful and didn't take any extra time.