For me (an amateur chef and big fan of Italian cuisine) it's not even close: Il Mulino by a country mile. Great upscale atmosphere, fantastic food and a very comprehensive wine list. It's probably the restaurant that reminded me most of my trips to Italy. They aren't on the dining plan (which is probably why I like it so much - keeps the crowds down and quality high), but they now accept the Tables in Wonderland card for annual passholders.
After Il Mulino, I'd probably go with Via Napoli for it's fun, casual approach. I've only dined at Tutto Italia once and found the food uninspired and the prices exorbitantly high for what you get. I wish it had stayed Alfredo's.
As far as Mama Melrose, only been there twice. Once was extremely good - a fantastic server, good food and a reasonable price. The second time, it was terrible. Clueless server, food was all burnt ... hated it.
Never been to Tony's at MK (heard nothing good about it) or Portobello (we always end up at House of Blues if were at DD for the night).