Have not heard anything official, but based on the size (60 something rooms from what I have heard) and the premium DIS will be able to charge for this makes it highly unlikely.
I am not expecting this spaceship being able to be booked for one night, or one week, but rather a "3 day voyage".
Also, DVC is, among other things, a way to have hotels run at 95%+ occupancy, which, to my understanding, is higher than typical hotel occupancy rates. I do not see this hotel, based on its theme and size, having less than 100% occupancy for years to come.
Then again, I have been wrong before, but Ill never admit it.