I recently tried a moderate hotel (Port Orleans Riverside) after usually staying in Deluxes (I've stayed in Swan, Grand Floridian, Yacht Club, Boardwalk Inn, Animal Kingdom Lodge and the Wilderness Lodge).
I really missed the deluxe amenities while staying in a moderate, if nothing else for the location and transportation. There is nothing like have the opportunities to take the motor launch boats between GF or Poly and MK, or take the monorail from Contemp., GF, Poly...I was really surprised how much it changed the feel of the stay to only have access to buses and have such long trips between parks and such. At AKL there are only buses but you are very close to Animal Kingdom, which is our favorite resort. In fact, we usually start our WDW stays w/ a few at AKL so we can frequent Animal Kingdom a lot and then move on to another hotel near Epcot or MK for the rest of the trip. AKL is also a FABULOUS hotel. At both AKL and GF you feel totally pampered. It is sublime. I would stay at the Dolphin or Swan before I would choose a moderate again, both for a more luxurious setting and the location/ transportation access--the Swan and Dolphin also have many great discounts that make them as affordable as moderates some of the time.