Have stayed in e Kissimmee/192 area before but 10 years ago so I don't feel in a position to comment.
My last 5 trips have been on I-Drive. Here's why we like it:
1. Whilst some areas (North of the Universal Blvd intersection) are tacky, the rest is actually very nice. This is particularly true of the area round the Convention Center. There are nicely planted gardens around the walkways, benches etc. and the area feels very well kept.
2. You are in walking distance of everything you could need - local Walgreens, restaurants, fast food and bars. We prefer not to drive as we enjoy having a drink when we are on holiday, so it's great to have literally hundreds of places to eat & drink within 10 minutes flat walk every evening.
3. There are excellent bus routes and it is easy to get around without renting a car. We travel with ease to several malls (Florida, Milennia), outlets (both Prime), theme parks (all of them), supermarkets (Publix) etc. We also find that this saves us a lot of money, though this is not the deciding factor for us.
4. The area feels safe and I have no problems walking in the area at night, even alone (female in my 20s).
We have another trip coming up soon and have chosen I Drive again - for us, it's a convenient and pleasant place to stay, with many hotels which meet our needs.
I will also say that I Drive has only improved since I have been visiting Orlando (first trip over 15 years ago), but especially in the last 5 years.