We drove for the 2nd time from central Mass, and it's not a problem! The first time it was just DH and I and we drove straight through there and home. It IS a long drive, but as long as you switch every couple of hours it's fine.
The trip we took 2 weeks ago included our 20 month old DD and a 5 month pregnant me

We left Saturday night, drove straight through to Sunday around 5 PM. We stopped in Florence, SC for the night (it was Superbowl Sunday... DH wouldn't have missed that for the world!!).
NOTE: If you're near northern SC and need a place to stay for the night, Florence has about 60 hotels all right off the highway. We stayed in the Marriot Courtyard... it was right off the highway, had an indoor pool (to keep me and DD occupied while DH watched the SB) and was brand new. It was $85/night. A little more pricey than the others in the area, but I really wanted that pool. The novelty of swimming in February was just too much for this New Englander to pass up!
Anyways... back to the trip. We could have made it to GA by 5, but DH took a big wrong turn in NJ while I was sleeping and we had to back track.

DD did so much better than we thought! I bought some inexpensive board books and games, and she looked at those for most of the trip. We woke on Sunday, and left around 9:30, making it to WDW around 4pm.
On the way home, we drove straight through. We left at 9:30 AM and just kept on going, making it home around 6:30 AM the next morning. That was with an hour and a half stop for dinner! It gets tough driving at night, but DH does great so I do most of the driving during the day and he does it at night.
On our way home we stopped in NC for dinner, and at a truck stop bought a 9" tv/vcr combo for $170! So on our next trip down (driving of course) we'll have that to entertain our DD and DS-on-the-way
Do the drive! It's like an adventure
