I did a girlfriend get a way last March for the first time and really enjoyed it. I was a bit worried about my friend because she was not a disney fanatic, but she loved it and was jealous when I went with my family a few months later.
As for the guilt, yes it was there. I had a hard time leaving my family but my kids were really good about it. Some days they would cry and say they wanted to come with me and other days they would say Mom you deserve it go and have a good time. The good thing was we had a family trip planned for 2 months later so they were able to think about that.
My friend and I have decided to make it annual trip, although last time I splurged for the one bedroom and the next time we may have do the studio.