When we used to drive all the time, before we discovered Amtrak, we first took I75, back in 1977. Its a long way to Cinncinnati before heading south but I77 wasn't built yet. Other trips, later, we down the I77 route, we're from the Youngstown area and it seems to be the quickest, but over a bunch of year, I began to hate the mountains alot. We squeeze in a drive trip few years ago, waited to long to book the train, and it was full, so we had to drive. Since hating the mountains, we decided to do the I75 route. Its much more pleasanter, low rolling hills, alot of 3 lanes. Time wise, I75 is a bit longer, by maybe 3 hours. We used to make the I77 trip to the World in 19 hours, non stop. Hope this helps.