Weeeelll, it took us just over 3 hrs from WDW to Pompano Beach. Then, it took us about an hour to get to Miami Beach from Pompano later in that trip. So, I would figure on almost 4 hrs total since you won't be getting off the highway and back on. I wouldn't make an overnight stop half way, if that's what you mean. You could stop to eat and get out and stretch though. Palm Beach might be a good place to do that.