When we stopped staying on Harbor, I was really concerned he would be upset or confused but he really wasn't bothered at all. We've stayed in various types of hotels over the years and he seems to do fine in all of them (*knock on wood.*) I think to him, the trip is more about the parks than anything else. He seems pretty indifferent about hotels. His understanding of things gets better each year too, which is really helpful. We show him a lot of pictures and stuff before we go places so I think if we prepared him for staying elsewhere, he'd be okay.
Of course, one never knows with him so anything is truly possible.