My dh is the designated FP runner. We have young children, so our strategies are based on that and, we generally only do FP's at MK since we dont ride a lot of FP attractions at other parks.
MK:
Dh grabs Buzz FP's while we hit dumbo. We meet over at Peter pan and do the rest of fantasyland then head to Tomorrowland, usually now it's time for Buzz, we do that then dh grabs FP's for Space Mountain while we head over to the other side of the park and do HM and Pirates. As soon as the window opens he'll grab BTMRR FP's. We then grab the train to toon town and walk to Space Mt. Back to Toon Town for a bit, grab the train and hit the FP for BTMRR.
We also use the strategy of getting fast passes with the kids tickets on rides that we baby swap for so we can ride twice or like at BTMRR and Splash, he'll get ours at one and the kids at the other so we can swap and do them both really close together.