Sure can. We did our 2006 trip to WDW at the Cabins..
We had myself, wife, 2 kids (6 and 7 at time) and in-laws.
Pros:
Very relaxed location. Great to come home at night and have your own cabin. You don't have to worry about neighbors
Full kitchen and outdoor grill. We did a few meals and loved it.
Great main pool. Nothing fancy, but they do tons of kids stuff and the playground/arcade is right there. Wife and I would relax, have an adult drink and kids would spend hours there
Nightly movie and campfire. Just super family time and memories
Launch to MK
Cons:
You should rent the golf cart. We did and was worth it, but expensive at $50 a day. Without it, you limit yourself. Plus driving around in the cart at night, we meet great people in tents/campers and made new friends.
Limited dining. If you are on Dining plan, you only have one one buffet restaurant. But with your dining in the cabin, this is a non issue if you are not on the plan.
One bathroom. With the inlaws this was an issue. I am still scarred from having the MIL using the bathroom while I was in the shower.. Someone hold me.

Our next trip, we did connecting rooms at POR and that was fine.
We loved the Cabins and without the Inlaws, we would go again. The bathroom and having to share the golf cart were a challenge.