Well I usually request that there are no comforters on the bed when I check in. I deal with health issues so I have to be extreme but frankly I am a germaphobe anyway!
Here are some tips. Ask to have the comforters removed before your arrival. Pick up a couple flat sheets at
walmart ( a twin flat sheet is fine even on a double its big enough) . They are like 3.00. Throw those over the existing sheets on the bed.
I buy space bags ( most stores sell these now) and pack a few blankets in one and suck all the air out so it wont take up any room. You could do this with pillows as well if you wanted. They puff right back up when you unseal the baq.
If you have any allergies I noticed on Disney site the other day that you can request a VIP cleaning. I think this is great for people with severe situations.
I also like clorex anywhere spray because it disinfects safely without a lot of chemicals . You can use it next to food even. And the smell of lysol gets to me after a while. This has no odor.
I always say that the people that get a room after me should thank me! lol By the time they check in I have throughly scrubbed the room !