I partly agree with above I would stay 2 nights in LA/Hollywood and do the touristy stuff there then move to Anaheim to do Disney and beaches.
We really like Hollywood area. There are plenty of things to see along the stars walk area at the chinese theatre area. You can do wax museum and ripleys. There is a good view of the Hollywood sign from the Hollywood and highland shopping area.
In Hollywood check out lowes Hollywood and Magic castle hotel for accommodation.
From here you can easily do Universal Studios and city walk area.
The grove shopping centre and Farmers Markets are great to visit. Griffith park is lovely to visit.
At Anaheim I strongly suggest staying off property at a hotel across the street in close walking distance.
We love Fairfield Inn by Marriott and the Howard Johnson.
In Anaheim you can spend days at Disney but also drive to some lovely beach areas (Huntington beach, laguna beach, Newport beach), do some shopping, drive to san diego (approx. 2 hours) to do
LEGOLAND, the zoo, seaworl.
We have always driven and find it fine.... takes a bit to get used to but not too bad.... as someone else said drivers are surprisingly very considerate.
If not we use Lansky Transport for our transfers and he is awesome.