We've done several two-week trips consisting of a stay at WDW,
DCL cruise, followed by another stay at WDW. We'll be doing another one next year.
We bring one suitcase per person, one rolling hang-up bag for dress clothes, a bag for my wife's shoes
, and a huge scuba bag (masks, fins, snorkels, and dive accessories for me and my son). All toiletries are travel-sized.
We don't typically unpack in a normal hotel room. In a cruise cabin, you have no choice. Almost everything gets unpacked and put away. Suitcases go under the bed (some inside others). Scuba gear stays in the bag until needed.
I've found that you don't actually need two weeks of clothes for a two-week WDW/DCL vacation. On the ship, we spend a lot of days in swimwear, and you only dress up for a few hours for dinner.
For our next trip, we'll be staying in a 2BR DVC room on both ends of the vacation, so we'll have a washer/dryer in the room. I plan to cut down on the clothes I bring even further. I hate doing laundry on the ship, though. Why waste valuable ship time in a laundry room?