Yes, AMEX is good. I always pay with the AMEX and transfer my Member Rewards points over to Southwest Rapid Rewards for free airline tickets. If you have a DVC loan you can also make your payments (or additional payments if you have if taken out automatically) on your AMEX.
I use AMEX too (even though I have the Disney Rewards Visa). When I build up enough points I use AMEX Membership Reward points to get Jet Blue plane tickets