Ah, the endless debate ...
Again, my vote - having done both several times - is the 79/77/etc. route. It's a shorter drive for you by a wide margain, and has just as many places to eat/stay as 75.
Now, I've heard weather brought up often as a consideration, and I agree there is the potential for hazardous winter driving along parts of the 79 route. However, the same is true for the "Snow Belt" around London, which you would be going out of your way to drive through to get to 75. My wife and I will be using 79 when we return home after New Year's in Orlando, and I'm not worried - I'll just keep an eye to the sky ...