Isn't 26/77 way out of your way coming from NE PA? We always traveled that way when coming from WNY and it was a good route, but I would think from NE PA you would be traveling really far west out of your way?
And to the OP - we live near Annapolis and it's usually about at least a 14 hour drive for us (+ hour or two depending on traffic, stops, etc.). I usually plan 14-16 hours. We don't take I-95 though until we get further south. We take 301 south normally because that's closer to our house and avoids going near DC. I'm guessing Annapolis to Syracuse is a 6-7 hour drive? (I'm so lazy, didn't even look it up on Google Maps!). So I think you are talking about 20-22 hours driving total.
We've done it from Buffalo numerous times - usually it was just over 20 hours or so, from what I recall.