I have driven this route many times, from the Lehigh Valley to WDW. In fact will be making the drive again this December.
I do not know what the tolls are as I use EZpass.
This will be the second time driving that I am actually stopping and not driving straight through. Last time we stopped in Jacksonville, FL overnight and that was just a bit too long of a drive for 1 day. THis time we will be stopping overnight in Savannah, Ga. Yes, it makes for a longer drive day 2 but much more manageable for 1 person.
It will take between 10 and a half - 13 hours to get to Savannah and then between 3 and a half - 5 hours to get to Orlando. All depends on traffic, stops and speed - which at times I go over the limit.
When we stayed at Jacksonville, we also had a 2hr delay on the highway due to an accident, not fun at all, just parked on I95.
Hope you have a safe drive.