Hi Bea,
We have driven down over 10 times and usually take the same route. We cross at the Thousand Islands Bridge and go south on 81. Then east on 66 for a short distance and then south east on 17 until I95. Then its 95 until I4. We take the bypass around Richmond (295? maybe) and depending on the time of day, we sometimes take the bypass around Jacksonville. Every couple of years, I will get another TripTik from CAA, and this is the route they map out for us. My parents are currently in Florida and their TripTik, that was prepared in January, also has this route. Recently, we have been driving straight through. Our last trip was 27 hours going down and 25 coming back. This time included stops for gas and meals. We have young kids, so we would stop for at least an hour each meal to let them play and use up some energy. I think it is approximately 2350 kms each way for us. We usually drive about 120 km/h which is about 4 mph over the normal speed limit of 65. We've never had a problem at this speed. Occasionally, the flow of traffic is faster and I normally just try and stick with the flow. From Kingston, Ricmond VA is approximately half way. If you take the same route we do, there is a group of motels on 17, approximately 30 minutes from Richmond that are nice and fairly priced.
If you are travelling in the winter, we have found that usually the worst weather (snow

) is between Watertown and Syracuse. I believe one trip it was snow/freezing rain as far south as South Carolina, but normally, it isn't bad once you hit PA.
The drive isn't nearly as bad as a lot of people think

Let me know if you have any other questions I might be able to answer.
Jeff