I just came back
I came from Hartford, but I think much of my experience applies to travel from MA
Here is a copy of what I put on another thread. I hope it helps:
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Background:
We travelled roundtrip using our Ford Windstar minivan (Hartford-Kissimmee). There were 6 of us (me, DW, DD18, DS11, DS10, DS9). We left July 2 and returned on July 17. This was our second trip driving to WDW (took the other one in July 2010).
The Trip There:
July 2: Hartford-Jacksonville. Left at midnight on July 2.
Took 84-684-Tappan Zee Bridge-87-287-78-81-77-26-95
The Tappan Zee bridge is far better than taking the George Washington Bridge. I-81 is a beautiful road and the speed limit is 70 mph most of the way. Saw lots of patrol cars (perhaps 100 - between Tappan Zee Bridge and Charlotte NC); I tried to stay 5 mph over the limit and never got pulled over. The kids slept until 9:30 am and we had breakfast just south of Christiansburg, VA. The construction just north of Christiansburg was very minor and really didn't impact travel at all. The truck traffic on I-81 wasn't an issue at all, but we were done with I-81 in the early morning before most of the trucks were on the road.
Hit heavy traffic in Charlotte, which turned into stop-and-go-traffic just north of Columbia, SC, which turned into stopped traffic just south of Columbia. Traffic was light once we made it to I-95. Made it to south of Jacksonville about 8pm.
July 4: Jacksonville-Kissimmeee. Left at 4pm after visiting relatives. No issues.
The Trip Back:
July 16: Kissimmeee - Wilson, NC. Left at 9:30am with a planned stop in Wilson, NC. Last year we "winged it" for our overnight stop - big mistake. it is much better to have a planned stop.
Took I4-I95. No issues with traffic/construction/police. However DS10 had the stomach flu, with the first barf coming an hour after we left. Made stops every couple of hours. Stayed at the Hoilday Inn Express in Wilson, NC. I highly recommend it. DS10 kept barfing through the night, so I didn't sleep well.
July 17: Wilson, NC - Hartford.
DW stayed with DS10 while we went to early church. Left at 10am.
Left I95 at Emporia, VA to take the Chesapeake Bay Bridge-Tunnel. DS10 felt completely better after some applesauce and crackers, so everyone really enjoyed going over the bridge. Travelled up the Delmarva peninsula. On the advice of this board, we took the eastern route (Route 113) to avoid speed traps. However, there are a LOT of traffic lights this way and it probably would have saved time to stay on Route 13 and simply go 5 mph under the speed limit.
When we got to NYC, I ignored the advice of my GPS and took the George Washington Bridge Big mistake. Waited an hour to get over the bridge. Made it home by midnight.
Summary
I-81 is a great road. However Charlotte-Columbia (I-77 and I-26) traffic was very heavy. There are side roads that may avoid this...be ready to take them. I'm not convinced that I-81/I-77 through VA/NC is better than I-95 through VA/NC...the traffic encountered around Columbia, SC was almost as bad as the I-95 traffic...thus the extra travel distance that is required to take the 81/77 instead of 95 may or may not be worth it.
Wilson, NC is a good midway planned stop. Lots of new clean hotels, restaurants and it is easy to access. The Holiday Inn was immaculate.
If you take the Chesapeake Bay Bridge-Tunnel (which adds 45 minutes to the trip over going through Washington DC), consider taking route 13 instead of 113 through Delaware...just drive well under the speed limit.
Avoid the George Washington Bridge. The Tappan Zee is a better alternative in every respect.
Be prepared for a sick child on the trip. Have plastic bags, paper towels, ice, crackers, applesauce, bottled water. We had all of these and I don't know what we would have done without them.
Have you car thoroughly checked out before you travel. We did and our minivan has 136,000 miles on it and we had no car problems at all.