We used to drive from Houston and I can definitely say that driving from Dallas is way worse. It's not only longer but I-20 makes I-10 look exciting.
We always liked to stop in Daphne Alabama. It's just on the other side of Mobile and has some nice places to stay. I always preferred to be past Mobile when we were ready to go the next day. If you can make it to Tallahassee, that's even better but it's tiring.
Coming back I always tried to make it to Lafayette but getting to Baton Rouge always seemed way easier. We never drove straight through.