I just drove Atlanta to Orlando this past week. I'm assuming you're taking I-75 to the Turnpike? Going down was worse than coming back. There were several areas around Macon that were down to one lane. (this was on the Macon bypass, which you should still take b/c even w/construction it is faster than going straight through Macon) Even driving down on a weeknight, we still ran into some backed up traffic. We didnt' sit for hours or anything like that, but it definitely slowed us down some. That was the only area that I recall being a problem. Once you get closer to Valdosta, it was smooth sailing the rest of the way. Just remember, that once you hit Florida there is nothing for quite a while. Take the bathroom break before you cross the state line!