I used Sea Bands on my last cruise and I am prone to motion sickness, but only on ships, not speed boats or cars, it is odd. The first cruise I went on in the early 90's, I had an inside cabin and I realized I was claustrophic and I was sick only at night. So, a couple years ago, I went on Carnival and had a stateroom with a balcony, but it only helped the claustrophobia, but I was still sea sick, only at night. So, last december I bought Sea bands and Dramamine, I only took 1 dramamine before the ship left, but after that I used the bands. As the ship started on it's way, the water was a little rough, because my dd was in the mickey pool and the water in the pool was swaying back and forth, but no sea sickness and the 2nd day I guess I got my sea legs or the water was really really calm, but I will be using the bands again in December again, better safe than sorry. My dd6 was making fun of me, because thankfully she doesn't get motion sickness, so when the ship started to leave, I had to hurry up and put the bands on and my daughter was saying, you better put them on before you get sick and she was laughing. You just have to find out what works for you. I had taken both because I wanted to try the bands because the dramamine had made me drowsy a couple years before that, and I really wanted to enjoy the cruise with my daughter. Good luck!