Misslissa; we have driven down both times, pulling a trailer. Generally. we were lucky and had fairly decent weather going down both times. Coming back, however, we ran into storms on both trips. Once, in the Tennessee mountains, and if there had been a safe place to stop and take a break for a while, we would have. That was scary. The second trip we hit a big storm through Ohio. Our advice would be to make sure you have built in some extra travel time for such things. We were only delayed by a few hours each trip coming home, so it wasn't a big deal. The way we look at it going down, if the trip is on schedule then we'll have extra time at WDW.
I'm not sure how you're going, but if you decide to hook up with the I75 you'll find it is an easy trip down. I highly recommend the book "Along the I75" (this is updated each year, spend the $20on a new one).