My grandparents take our luggage with them, as they start driving to Florida several days ahead of us (they make a road trip out of it with a couple stops along the way), so we don't have to worry about packing anything, as it's already been done.
We make dinner at home because we'll be eating out for the next week. It's usually spaghetti. DS packs his toy bag, then it's bath and bed for him. I stay up, surf the DIS for last minute tips. I pack the kids' snacks for the airport/plane then I pack the laptop and anything else we didn't get into the luggage. Funny enough, for several trips in a row the Jon & Kate plus 8 episode when they went to WDW happened to be on TV as I was going to sleep, so I'd watch that. Now that they're not on re-runs anymore, I flip on one of our DVRed WDW shows and (try to) fall asleep.