Count me in the group that frets over inviting some guests over because they are so completely anal about cleanliness. My aunt didn't get an invite to my house for 35 years because my mom feared her judgement. It was plain stupid because that fear ended up keeping my dad from visiting with his brother and us knowing our cousins growing up.
We rarely got an invite to my aunt's house for much the same reason. In the end, you just have to let things slide and realize what is more important.
Now it is damn hard to keep a house when you are working, having lots of kids (they are mess factories) or like me are disabled. There are parts of my house that get dust in a matter of hours, but since i don't use them much they are not on my priority list for cleaning.
I also share a house with my dad that is the family home and thus has about 40 years of clutter. We have stuff from my grandparents, stuff my siblings, stuff from my aunts & uncles, and our stuff. It's hard to know where to put it all. And we live in the country so insects are always a problem. The last two years there's been a stinkbug epidemic. Try as hard as you can you can never seem to eradicate all the little buggers or keep them from crawling into your home. (Yes we've sprayed, yes we've cleaned them up and still they keep coming back.)
Saying that we did give the house a full cleaning, at least as far as the first floor went. Everything was dusted, vacuumed, polished and cleaned. That was back breaking work leaving both my dad and I hurting and exhausted. And we cooked, wrapped presents, decorated and hosted a gathering of 17 people.
I'm sure there are parts of my house some anal folks will step into and complain about. Go through my laundry room to get soda from the pantry and you have to walk by the cat boxes. Study the disused corner window and you'll probably find a stinkbug crawling in. Go to my basement and there's several decades worth of stuff we've accrued, some of it kept intentionally other stuff we're holding for others. My upstairs has 2 cleaned and sorted bedrooms and two rooms holding a collection of clutter in a state of temporary flux.
But I'm not going to make the same mistake my mom did. I refuse to be so worried about other people's opinions I won't invite them over for a simple gathering. I still wash my hands before I prepare food and use clean dishes.
Oh and by the way, having 17 people in your house creates a mess all of its own. Especially when several are children. I spend much of Christmas night cleaning up all the discarded candy wrappers, half consumed soda cans and bits of wrapping paper strewn about. Then there are the sofa pillows that need to be fixed and gaming devices put away. Fortunately I get help from some of the family that visits.