Well.... I've been lurking to see what everyone has. Ah..the search for the "perfect bag".
My gear= Nikon D80, 50, 18-135, 70-300
Future gear= (Groucho's

) fisheye, WA 2.8
I have a Lowepro micro-trekker to shlep all my gear to where I'm going which works for me
http://products.lowepro.com/product/Micro-Trekker-200,1963,14.htm
and then a toploader for daily use
http://products.lowepro.com/product/Toploader-75 AW,2058.htm
This is fine for me and my Disney trips, local USA...but... I'll be in Europe in late April/ all May and have a real concern about safety and more room for stuff. I'm looking for something more secure, maybe pc compatible (for my papers/nikon books..not pc) and hopefully not humongous...
Tried out the fastpack 250 yesterday...its almost bigger than me !!

The flipside looks good..but no room for Xtra stuff...Hummmm

The search goes on...
Maybe I don't need all my gear??