The Wine & Dine 1/2 marathon is a night time race so the race should not interfere with your park days. The race takes place in AK, HS and Epcot but after all the parks are closed. That weekend however, it will probably be crowded but not just from the race but from other holidays/school breaks occurring at the same time. The night races at Disney have very little impact on the parks themselves except for an increase in the number of people that will be in the parks. We find that avoiding Epcot on Food & Wine weekends is best in any event as the park is very crowded with locals and can get very rowdy with drunk people all over the place. If you can avoid Epcot on the weekends I would do that.