I agree that it depends on what parks you are going to and how often you plan to dine in the FW restaurants. The 2200 loop is the most centrally located cabin loop, so if you are spending a lot of time at MK and/or the Settlement to dine, it is a good choice. If you don't rent a golf cart, be aware that the 2200 stop is the last cabin pickup before going to the Settlement (there are other stops after the cabins), and 2800 is closest to the Outpost where you go to the other parks. Depending on when you are riding, the buses can be full, or nearly empty. Personally, since we do not try to go to the parks by bus at park open or return at park close, we haven't had issues getting a seat on the bus.
We rented a golf cart primarily so we could drive around the campground to admire the Christmas decorations. We could have used it to drive to the Settlement or Outpost depots but we drove to all the parks except MK.
I have stayed in 2200, 2400, 2500, and 2700. All of them have their pros and cons, but none of them were bad in any way. We don't request a specific loop, preferring an early check in request to a loop request.