Even though is a longer drive (2 hours vs. 1 hour to the east coast) I would choose the Clearwater Beach (Honeymoon Island) area. There are so many things to do and the beaches are absolutely beautiful. We have been to the east coast, but it just isn't the same!
Lots to do in the Clearwater Beach area: pirate cruises, dolphin watching, deep sea fishing, the Pier, Caladesi Island up the coast, shopping & great restaurants.