I went to Sanibel for the second time this April, and it was wonderful. It is very laid-back "old Florida". There are no highrises, not much nightlife. There are hotels, cottages and condos right on the beach. Much of the island is the Ding Darling wildlife refuge, where you can bike, kayak or take an informative tram tour and see all kinds of wildlife. The "Sanibel Thriller", a speedboat ride where you learn about the island and dolphins ride the wake of the boat, is a must-do. There's bike paths all around the island. You can also visit Captiva island, attached by a bridge. The main draw is the beach and the shells, which are amazing. Lots of nice little restaurants and shops. The best place to get info is to check out the Sanibel forum on Tripadvisor; most accomodations and restaurants are reviewed by real people. Please feel free to PM me with any questions. I've already booked my condo for next April (my son's school vacation). It's one of my favorite places on earth.