Your 22 mo. will love it!
You will be amazed at how many rides you can go on with her.
We took our son at 18 mo. and 26 mo. (with older siblings too). He is now 32 mo. When he sees a commercial or anything Disney he can't wait to go back. He loved the characters and shows.
Definitely do MK and AK. HS has Playhouse Disney, Little Mermaid, Beauty and the Beast, and Muppets, and although she can go on other attractions, you may not want to. WHen we went the first time it wasn't until half way through the day that I realized that everything he was seeing he thought was real. Some of the attractions can be scary when they are that young (Great Movie Ride, Backlot Tours, Indiana Jones.) Epcot doesn't have much, except Nemo, but World Showcase is great during nap time in the stroller.
You will have a great time.