We took DS who had just turned 2 for his first trip in January. I was so nervous that he would get sick especially because it was during cold & flu season. Before we left I was sure to get him to bed on time most nights, get naps in, drink plenty of juice and not over-expose him to other kids. On the plane I just clorox wiped the seat, armrests, window area, and tray. Then when we got checked into our room at POP I brought Clorox Anywhere (best stuff!!!) and sprayed everything down. I know the room was cleaned but I sprayed things that were low to the ground, remote control, doorknobs, phone, etc... I wasn't going to take any chances. We also didn't keep too many late nights, that's why we went during Value Season, and made sure he was well fed and well rested!