Most Patients Don't Reach Cholesterol Goals
By Peggy Peck
WebMD Medical News
Feb. 28, 2000 (Cleveland) -- High cholesterol -- especially too much LDL-C, the so-called bad cholesterol -- is a known risk factor for heart disease, but a new study suggests that
most people who are treated for high cholesterol fail to lower it enough to meet target levels.
Researchers from the study, called the Lipid Treatment Assessment Project (L-TAP), say that
only 38% of the 4,888 people they studied achieved their goal cholesterol levels. This is a troubling finding, they suggest, since the study was designed to track the effectiveness of treatments by physicians in the community. When researchers test drugs in the controlled environment of clinical trials, the results are often impressive, but critics maintain that those results may not be reproducible in the everyday clinical setting.
"I think it's an educational thing. We've just got to keep educating doctors," Joseph S. Alpert, MD, tells WebMD. "It just takes time to get people to do it. We have the same problem with other diseases." Alpert, who heads the department of medicine at the University of Arizona Health Sciences Center, was not involved in the study.
The researchers, led by Thomas A. Pearson, MD, PhD, of the University of Rochester School of Medicine, had the same concern. Writing in the Archives of Internal Medicine, they conclude that more aggressive treatment of high cholesterol is needed to reach the goals established in guidelines set by the National Cholesterol Education Program (NCEP).
The study supported by a research grant from the Parke-Davis pharmaceutical company of Morris Plains, N.J., looked at patients who were undergoing treatment by 619 primary care physicians. The patients, aged 20-75, were treated with either lipid-lowering drug therapy or diet. Investigators divided patients into three groups: Low-risk patients, who had no evidence of coronary heart disease (CHD) and fewer than two risk factors for it; high-risk patients, with two or more risk factors and no evidence of heart disease; and patients who actually had heart disease. Risk factors included age (45 or older for men and 55 or older for women), family history of heart disease, cigarette smoking, hypertension, and diabetes.
Only 38.4% of patients in the study achieved their target levels of LDL-C. The success rate was highest among the low-risk group (68%), followed by patients in the high-risk group (37%), and was lowest among patients with CHD (18%), the researchers write. Among those in the high-risk group, the more risk factors a patient had, the more successful treatment was.
"When you have an effective therapy, those who are most severely affected are going to benefit the most," Alpert says.
Another finding was the link between diet and success. Although only 34% of the 751 patients who were treated with diet instead of drug therapy achieved the target LDL-C level, "compliance with diet still contributed to LDL-C lowering and remained a significant predictor of success," the researchers write. This could be interpreted to mean that patients who comply with diet guidelines might also be more compliant with medication, they say.
"You are picking out people who are going to comply. A person who ignores the diet might also be someone who forgets to take their medicines," Alpert tells WebMD.
The authors suggest that an explanation for the poor results could be the lower-key approach of primary care physicians, who may not be as aggressive as investigators in clinical trials. For example, few primary care physicians used high doses of lipid-lowering drugs. The researchers conclude that the only way to meet the NCEP objectives is to use more drug therapy when diet alone fails to lower cholesterol, to concentrate on statin drugs, and to increase doses to achieve target levels.
Alpert tells WebMD, "Patients should participate in their own care. The NCEP project puts those numbers out there. These are the numbers you should be at. If you're not there, you should push your doctors. As always in these situations, you need to take some responsibility of your own health."
The NCEP guidelines for LDL-C levels may be found on this page:
http://rover.nhlbi.nih.gov/health/public/heart/chol/fabc
Most people who seek treatment for high cholesterol levels don't lower cholesterol enough to meet target levels, according to a study in the Archives of Internal Medicine.
Patients' diets contributed to lowering of LDL-C levels, which could mean those who comply with diet guidelines might also be more compliant with medication.
Researchers suggest that cholesterol treatment needs to be more aggressive so more patients can achieve their target cholesterol levels.