The answer is YES!!! I'm working one right now and it's been such a blessing for my family. The job I'm currently working probably isn't hiring right now, I'm an "Ads Quality Rater" for Google. I think it might be one of the best jobs in the world, but like I said, they don't open up hiring for it very often. You can search for the job on the career section of Google's corporate homepage with the phrase "ads quality rater" or the abbreviation "aqr". If you find that they are currently hiring and you'd like some tips about what to expect with the application process feel free to pm me.
Most at home jobs are telephone jobs in customer service, Uhaul hires at home telephone reps. I applied for that job at the same time that I applied for the Google job and I never heard back from them. I don't remember exactly how I applied for that job, but I think there was an option on a drop-down menu when I went to uhaul's career site. Apple and
Amazon also hire at home workers.
I wanted to avoid putting my youngest in daycare, so a few years ago I started looking for info about legitimate work at home jobs and I stumbled across a page on About.com called the Work At Home Moms page: workathomemoms.about.com/od/
About.com is mostly a search engine, but they hire experts in certain fields to maintain info pages, and the expert that maintains the work at home moms page researches jobs with legitimate companies that are telecommuting jobs. It's a great source and I will forever be grateful to About.com and Google for giving me the opportunity to help my family these last couple years. My employment contract will end in July so I'm actually going to be using the work at home moms page again to look for another job.
Edit because after I typed this I searched the job openings at Google and there are no AQR positions available right now. But I also looked at the jobs at Uhaul (because I had it saved in my bookmarks menu) and there are currently 3 work from home positions that they are hiring for. At the bottom of the main page for Uhaul you need to find the link for "career opportunities", click that and then click on "moonlighter jobs", then "contact center jobs", then "work from home opportunities". If I recall correctly from when I was looking at the job myself, I think they only pay about $10/hr, but I believe that if you worked in one of the sales positions there were bonuses or commission for up-selling. It's been 2 years since i looked into the job though, so that may not be accurate info.