While I was deciding whether or not to accept a job that was a 90 minute drive each way, HR called and said a raise over what I'd been offered had been approved, to offset the costs of commuting. That helped me decide to take the job, but the commute got old, fast, even though I WAS driving to Bar Harbor, ME- drop dead beautiful drive, but LONG drive. I was not unhappy when the grant funding wasn't renewed, so my position evaporated.
One thing to consider is your age. I don't know how old you are but your mention that your wife is getting ready to retire made me think that maybe you are, too. I have recently been looking to change my job and what I am finding is that, even though fully qualified, I don't get the interviews. Someone finally mentioned that employers don't necessarily want to hire someone who is going to retire in 5 years... so there's that to consider, too (if it's a consideration for you).